- PD-L1 inhibitor 1
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- $5.50 / 1KG
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2020-01-10
- CAS:1675203-84-5
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 1kg,10kg,100kg
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| | PD-L1 inhibitor 1 Basic information |
| Product Name: | PD-L1 inhibitor 1 | | Synonyms: | PD-L1 inhibitor 1;PD1-PDL1 inhibitor 2;N-[2-[[[2-Methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]acetamide;BMS-202;Acetamide, N-[2-[[[2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]-;PD 1 inhibitor 2;PD1 inhibitor 2;PD-1 inhibitor 2 | | CAS: | 1675203-84-5 | | MF: | C25H29N3O3 | | MW: | 419.52 | | EINECS: | | | Product Categories: | | | Mol File: | 1675203-84-5.mol |  |
| | PD-L1 inhibitor 1 Chemical Properties |
| Boiling point | 611.4±55.0 °C(Predicted) | | density | 1.133±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml) | | pka | 16.06±0.46(Predicted) | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| | PD-L1 inhibitor 1 Usage And Synthesis |
| Description | The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM. | | Uses | BMS-202 is a Novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface. | | References | 1) Zak?et al.?(2016),?Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1);?Oncotarget?7?30323
2) Guzik?et al.?(2017),?Small-molecule inhibitors of the programmed cell death -1/programmed cell death -ligand 1(PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1;?J. Med. Chem.?60?5857 |
| | PD-L1 inhibitor 1 Preparation Products And Raw materials |
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