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| | ROR gamma-t-IN-1 Basic information |
| Product Name: | ROR gamma-t-IN-1 | | Synonyms: | ROR gamma-t-IN-1;GSK805;GSK805
(GSK-805);N-(2,6-dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one;Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-;N-[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)benzeneacetamide;N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide | | CAS: | 1426802-50-7 | | MF: | C23H18Cl2F3NO4S | | MW: | 532.36 | | EINECS: | | | Product Categories: | | | Mol File: | 1426802-50-7.mol |  |
| | ROR gamma-t-IN-1 Chemical Properties |
| Boiling point | 617.1±55.0 °C(Predicted) | | density | 1.434±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF:3.0(Max Conc. mg/mL);5.64(Max Conc. mM)
DMSO:68.33(Max Conc. mg/mL);128.36(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.56(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);93.92(Max Conc. mM) | | form | A crystalline solid | | pka | 12.33±0.70(Predicted) | | color | White to off-white |
| | ROR gamma-t-IN-1 Usage And Synthesis |
| Description | GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor''s putative ligand binding domain without exerting significant effects on DNA binding. It inhibits the expression of IL-17 (at 0.5 μM) in naïve CD4+ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction. |
| | ROR gamma-t-IN-1 Preparation Products And Raw materials |
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