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| Product Name: | FIIN-2 | | Synonyms: | FIN-2;N-[4-[[3-(3,5-Dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-2-propenamide;FIIN-2;2-Propenamide, N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-;CS-1618;FIIN2;FIIN-2;FIIN 2;inhibit,FGFR,FIIN2,FIIN 2,Fibroblast growth factor receptor,Inhibitor,FIIN-2 | | CAS: | 1633044-56-0 | | MF: | C35H38N8O4 | | MW: | 634.73 | | EINECS: | | | Product Categories: | | | Mol File: | 1633044-56-0.mol |  |
| | FIIN-2 Chemical Properties |
| density | 1.306±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≥31.75 mg/mL in DMSO; insoluble in H2O; ≥3.39 mg/mL in EtOH with gentle warming | | form | solid | | pka | 13.51±0.70(Predicted) | | color | White to off-white |
| | FIIN-2 Usage And Synthesis |
| Description | FIIN-2 is an irreversible FGFR inhibitor with IC50 values of 3.09, 4.3, 27, and 45.3 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It has been shown to inhibit cell proliferation of transformed Ba/F3 cell lines and demonstrates antiproliferative activity in cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2. By inhibiting FGFR in a zebrafish developmental model, FIIN-2 caused mild to severe alterations in tail morphogenesis similar to the phenotypes reported following genetic knockdown of FGFR. | | Uses | FIIN 2 is FGFR inhibitor. It can be used in biological study of DFG-out mode of inhibition by an irreversible Type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors |
| | FIIN-2 Preparation Products And Raw materials |
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