Company Name: |
Borenpharm Co., Ltd
|
Tel: |
027-65563561 |
Email: |
sales@borenpharm.com |
Products Intro: |
Product Name:Propargyl-peg3-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite CAS:1391728-01-0 Purity:95% HPLC Package:1g; 5g Remarks:1.5g
|
Company Name: |
Jinan elephant international trading co., LTD
|
Tel: |
|
Email: |
13006575422@163.com |
Products Intro: |
Product Name:Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite CAS:1391728-01-0 Purity:99% HPLC Package:5KG;1KG
|
|
| Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Basic information |
Product Name: | Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite | Synonyms: | Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite;O-2-cyanoethyl-O'-(3,6-dioxanon-8-ynyl)-N,N-diisopropylphosphoramidite;Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[2-(2-propyn-1-yloxy)ethoxy]ethyl ester;2-cyanoethyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl) diisopropylphosphoramidite | CAS: | 1391728-01-0 | MF: | C16H29N2O4P | MW: | 344.39 | EINECS: | | Product Categories: | | Mol File: | 1391728-01-0.mol | ![Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Structure](CAS/20200611/GIF/1391728-01-0.gif) |
| Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Chemical Properties |
Boiling point | 387.2±37.0 °C(Predicted) | pka | 3.53±0.70(Predicted) |
| Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Usage And Synthesis |
Biological Activity | Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Preparation Products And Raw materials |
|