| Company Name: |
Shenzhen SUNGENING Bio-Medical Co., Ltd.
|
| Tel: |
0755-28967200 13631290199 |
| Email: |
wxf@sungening.com |
| Products Intro: |
Product Name:PF-4800567 Hydrochloride
CAS:1391052-28-0
Purity:99% HPLC or More Package:10MG;25MG;50MG;100MG
|
| Company Name: |
Shanghai Biopharmaleader Co., Ltd.
|
| Tel: |
+86 18721201413 |
| Email: |
sales@biopharmaleader.com |
| Products Intro: |
Product Name:PF-4800567 HCl
CAS:1391052-28-0
Purity:98%HPLC Package:10g,100g
|
|
| | PF-4800567 HCl Basic information |
| Product Name: | PF-4800567 HCl | | Synonyms: | PF-4800567 HCl;3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine:hydrochloride;PF-4800567 hydrochloride >=98% (HPLC) | | CAS: | 1391052-28-0 | | MF: | C17H19Cl2N5O2 | | MW: | 396.27 | | EINECS: | | | Product Categories: | | | Mol File: | 1391052-28-0.mol |  |
| | PF-4800567 HCl Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | Soluble to 100 mM in DMSO | | form | Powder | | color | white to beige |
| | PF-4800567 HCl Usage And Synthesis |
| Uses | PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock. | | Biological Activity | PF-4800567 is a casein kinase 1e (CK1e) selective inhibitor (IC50 = 32 nM) th at is 20 fold selective for the CK1e isoform over CK1d. PF-4800567 blockes CK1e-mediated PER3 nuclear translocation, but does not effect the circadian clock in animal studies.', 'PF-4800567 is also known as (3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride). It can block the epidermal growth factor receptor (EGFR) at micromolar concentrations. PF-4800567 helps to improve the locomotor stimulant reaction to methamphetamine (MA) and fentanyl. | | storage | Desiccate at RT |
| | PF-4800567 HCl Preparation Products And Raw materials |
|