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Product Name:Oleoyl 3-carbacyclic Phosphatidic Acid
CAS:779333-58-3
Purity:>98% Package:1mg;10mg;50mg;100mg;
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Product Name:Oleoyl 3-carbacyclic Phosphatidic Acid Exclusive
CAS:779333-58-3
Purity:98% Package:1mg (solution); 10mg (solution); 500ug (solution); 5mg (solution) Remarks:Medbio
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Product Name:Oleoyl 3-carbacyclic Phosphatidic Acid
CAS:779333-58-3
Purity:>=95% Package:500μg
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Product Name:Oleoyl 3-carbacyclic Phosphatidic Acid
CAS:779333-58-3
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| | Oleoyl 3-carbacyclic Phosphatidic Acid Exclusive Basic information |
| | Oleoyl 3-carbacyclic Phosphatidic Acid Exclusive Chemical Properties |
| Boiling point | 515.7±52.0 °C(Predicted) | | density | 1.04±0.1 g/cm3(Predicted) | | solubility | PBS (pH 7.2): 5 mg/ml | | pka | 2.70±0.40(Predicted) |
| | Oleoyl 3-carbacyclic Phosphatidic Acid Exclusive Usage And Synthesis |
| Description | Cyclic phosphatidic acids (cPAs) are naturally occurring analogs of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phosphate.1,2 Carba-derivatives of cPA (ccPA) are modified at the sn-2 (2-ccPA) or sn-3 (3-ccPA) linkage, preventing the opening of cPA to produce lysophosphatidic acid (LPA).3 Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) is a cyclic LPA analog that contains the 18:1 fatty acid, oleate, at the sn-1 position of the glycerol backbone.3 At 25 μM, it inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers in response to fetal bovine serum (90.1%) or LPA (99.9%) without affecting proliferation.3 3-ccPA 18:1, at 0.1-1.0 μM, significantly inhibits autotaxin,4,5 an enzyme that is important in cancer cell survival, growth, migration, invasion, and metastasis. | | Definition | ChEBI: Oleoyl 3-carbacyclic Phosphatidic Acid is a fatty acid ester. | | References | 1. Kobayashi, T., Tanaka-Ishii, R., Taguchi, R., et al. Existence of a bioactive lipid, cyclic phosphatidic acid, bound to human serum albumin Life Sci. 65(21),2185-2191(1999).
2. Mukai, M., Imamura, F., Ayaki, M., et al. Inhibition of tumor invasion and metastasis by a novel lysophosphatidic acid (cyclic LPA) Int. J. Cancer 81,918-922(1999).
3. Uchiyama, A., Mukai, M., Fujiwara, Y., et al. Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid Biochim. Biophys. Acta 1771,103-112(2007).
4. Baker, D.L., Fujiwara, Y., Pigg, K.R., et al. Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis J. Biol. Chem. 281(32),22786-22793(2006).
5. Prestwich, G.D., Gajewiak, J., Zhang, H., et al. Phosphatase-resistant analogues of lysophosphatidic acid: Agonists promote healing, antagonists and autotaxin inhibitors treat cancer Biochim. Biophys. Acta 1781,588-594(2008). |
| | Oleoyl 3-carbacyclic Phosphatidic Acid Exclusive Preparation Products And Raw materials |
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