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| | Propargyl-PEG4-thiol Basic information |
| Product Name: | Propargyl-PEG4-thiol | | Synonyms: | Propargyl-PEG4-thiol;HC≡C-CH2-PEG4-SH;Propyne-PEG4-thiol;SH-PEG4-ALKYNE;ALKYNE-PEG4-THIOL;3,6,9,12-Tetraoxapentadec-14-yne-1-thiol;CAS_1347750-80-4 | | CAS: | 1347750-80-4 | | MF: | C11H20O4S | | MW: | 248.3391 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1347750-80-4.mol |  |
| | Propargyl-PEG4-thiol Chemical Properties |
| Boiling point | 332.9±37.0 °C(Predicted) | | density | 1.064±0.06 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 9?+-.0.10(Predicted) |
| | Propargyl-PEG4-thiol Usage And Synthesis |
| Description | Propargyl-PEG4-thiol is a crosslinker containing a propargyl group and thiol group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. | | Biological Activity | Propargyl-PEG4-thiol is a PROTAC linker and belongs to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs). | | in vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target | | Non-cleavable < span> | PEGs | |
| | Propargyl-PEG4-thiol Preparation Products And Raw materials |
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