AD 0261
| 中文名称 | AD 0261 |
|---|---|
| 中文同义词 | 化合物 T10253;化合物 AD 0261 |
| 英文名称 | AD 0261 |
| 英文同义词 | AD 0261;Phenol, 2-[[3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]propyl]amino]-4-methyl- |
| CAS号 | 145600-69-7 |
| 分子式 | C27H31F2N3O |
| 分子量 | 451.55 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 145600-69-7.mol |
| 结构式 |  |
AD 0261 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
AD 0261是一种自由基清除剂，能够有效抑制脂质过氧化物和超氧化物阴离子的产生。
AD 0261 displays strong inhibitory action on the generation of lipid peroxides (IC 50 =0.022 μM) and superoxide anions (IC 50 = 0.9-4.0 μM). AD 0261 inhibits cytokine release and/or production from PHA-P-stimulated lymphocytes in a dose-dependent manner. AD 0261 inhibits all parameters which are indicative of lymphocyte activation with 50% inhibition being achieved in a range of 1-10 μM. AD 0261 suppresses ornithine decarboxylase activity, the IC 50 value being around 1.0 μM.