105102-18-9
中文名称 | 105102-18-9 |
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中文同义词 | 化合物 T17093;化合物 TIBENELAST SODIUM |
英文名称 | Tibenelast (sodium) |
英文同义词 | Tibenelast (sodium);5,6-diethoxy-1-benzothiophene-2-carboxylate |
CAS号 | 105102-18-9 |
分子式 | C13H13NaO4S |
分子量 | 290.31 |
EINECS号 | |
相关类别 | |
Mol文件 | 105102-18-9.mol |
结构式 |
105102-18-9 性质
储存条件 | Store at -20°C |
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溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
颜色 | 白色至米白色 |
phosphodiesterase
The effect of the phosphodiesterase inhibitor Tibenelast, and placebo on isoproterenol-induced changes in heart rate, cAMP and norepinephrine levels in normal male volunteers is studied. Tibenelast increases the heart rate response to isoproterenol infusion, whereas norepinephrine and cAMP levels are not different in any treatment.
Tibenelast is a potent orally active compound against anaphylactic shock induced by high dose antigen aerosol. When a lower aerosol challenge (0.05 mg/mL) is employed, bronchoconstriction is observed with a concomitant increase in lung resistance (RL) and a fall in dynamic compliance (Cdyn). Tibenelast at 25 mg/kg p.o. prevents these changes. Tibenelast is 10 times more potent than Aminophylline by i.v. administration; normalization of pulmonary function is achieved at 1 mg/kg i.v. Tibenelast is synergistic with epinephrine. The oral dose response curve of Tibenelast is enhanced with the co-administration of epinephrine. Tibenelast may be of significant value in the treatment of asthma and other respiratory diseases.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-101705 | Tibenelast sodium | 1 mg | 818元 | |
2024/08/19 | HY-101705 | 105102-18-9 Tibenelast sodium | 105102-18-9 | 5mg | 1800元 |