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Cyclopentanone, 2,5-bis(2-thienylmethylene)-

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Cyclopentanone, 2,5-bis(2-thienylmethylene)- Suppliers list
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem
Company Name: Riedel-de Haen AG  
Tel: 800 558-9160
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Products Intro: Product Name:PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem
CAS:1087-07-6
Cyclopentanone, 2,5-bis(2-thienylmethylene)- Basic information
Product Name:Cyclopentanone, 2,5-bis(2-thienylmethylene)-
Synonyms:Cyclopentanone, 2,5-bis(2-thienylmethylene)-;PPM1D Phosphatase Inhibitor - CAS 1087-07-6 - Calbiochem
CAS:1087-07-6
MF:C15H12OS2
MW:272.39
EINECS:
Product Categories:
Mol File:1087-07-6.mol
Cyclopentanone, 2,5-bis(2-thienylmethylene)- Structure
Cyclopentanone, 2,5-bis(2-thienylmethylene)- Chemical Properties
Melting point 226 °C
Boiling point 484.7±45.0 °C(Predicted)
density 1.363±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
form Yellow solid
Safety Information
MSDS Information
Cyclopentanone, 2,5-bis(2-thienylmethylene)- Usage And Synthesis
General DescriptionA cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC50 = 8.4 μM), while exhibiting little activity against PPM1A even at concentrations as high as 100 μM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF50 = 0.13, 0.17 & 0.48 μM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF50 = 34 & >50 μM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.
Cyclopentanone, 2,5-bis(2-thienylmethylene)- Preparation Products And Raw materials
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