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Chemleader Biomedical Co., Limited.
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Product Name:Maleimide-NH-PEG6-CH2CH2COOPFP Ester
CAS:1599432-34-4
Purity:97%+ Package:1g;5g;10g;50g;100g;500g;1kg Remarks:Biochemical Reagents; Pharmaceutical Intermediates
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| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 15801484223; |
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psaitong@jm-bio.com |
| Products Intro: |
Product Name:Mal-NH-PEG6-CH2CH2COOPFP ester
CAS:1599432-34-4
Purity:95% Package:100mg;250mg;1g
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| | Maleimide-NH-PEG6-CH2CH2COOPFP Ester Basic information |
| Product Name: | Maleimide-NH-PEG6-CH2CH2COOPFP Ester | | Synonyms: | Maleimide-NH-PEG6-CH2CH2COOPFP Ester;Mal-NH-PEG6-CH2CH2COOPFP ester;4,7,10,13,16,19-Hexaoxa-22-azapentacosanoic acid, 25-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-23-oxo-, 2,3,4,5,6-pentafluorophenyl ester;Mal-amido-PEG6-PFP Ester | | CAS: | 1599432-34-4 | | MF: | C28H35F5N2O11 | | MW: | 670.58 | | EINECS: | | | Product Categories: | | | Mol File: | 1599432-34-4.mol |  |
| | Maleimide-NH-PEG6-CH2CH2COOPFP Ester Chemical Properties |
| Boiling point | 736.0±60.0 °C(Predicted) | | density | 1.345±0.06 g/cm3(Predicted) | | pka | 15.01±0.46(Predicted) |
| | Maleimide-NH-PEG6-CH2CH2COOPFP Ester Usage And Synthesis |
| Biological Activity | Mal-NH-PEG6-CH2CH2COOPFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Maleimide-NH-PEG6-CH2CH2COOPFP Ester Preparation Products And Raw materials |
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