| Company Name: |
Shanghai PharmaPartner Co., Ltd.
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| Tel: |
13621689085 |
| Email: |
pharmabridge@163.com |
| Products Intro: |
Product Name:GNF-8625
CAS:1196546-33-4
Purity:98% Package:100mg, 500mg, 1g, 5g, 10g, 20g, 50g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:GNF-8625
CAS:1196546-33-4
Purity:0 Package:100mg/RMB 17500;50mg/RMB 13800;25mg/RMB 10600
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| | GNE-8525 Basic information |
| Product Name: | GNE-8525 | | Synonyms: | GNE-8525;GNF-8625;4-Piperidinol, 1-[6-[6-[(2R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl][2,4'-bipyridin]-2'-yl]- | | CAS: | 1196546-33-4 | | MF: | C31H30FN7O | | MW: | 535.61 | | EINECS: | | | Product Categories: | | | Mol File: | 1196546-33-4.mol |  |
| | GNE-8525 Chemical Properties |
| density | 1.39±0.1 g/cm3(Predicted) | | pka | 14.70±0.20(Predicted) |
| | GNE-8525 Usage And Synthesis |
| Description | GNE-8525 is a potent and selective pan-TRK inhibitor. GNE-8525 demonstrated potent antiproliferation activity with IC50 = 0.003 μM. In a tumor xenograft model derived from the KM12 cell line, GNE-8525 demonstrated in vivo antitumor efficacy when administered at ascending doses twice daily (bid) for 14 days in rats. Deregulated kinase activities of tropomyosin receptor kinase (TRK) family members have been shown to be associated with tumorigenesis and poor prognosis in a variety of cancer types. In particular, several chromosomal rearrangements involving TRKA have been reported in colorectal, papillary thyroid, glioblastoma, melanoma, and lung tissue that are believed to be the key oncogenic driver in these tumors. |
| | GNE-8525 Preparation Products And Raw materials |
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