Val-Ala-PAB manufacturers
- Val-Ala-PAB-OH
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- $0.00 / 1g
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2024-03-29
- CAS:1343476-44-7
- Min. Order: 1g
- Purity: >95.00%
- Supply Ability: 1g
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| | Val-Ala-PAB Basic information |
| Product Name: | Val-Ala-PAB | | Synonyms: | Val-Ala-PAB;CS-2747;(2S)-2-amino-N-[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]-3-methylbutanamide;L-Alaninamide, L-valyl-N-[4-(hydroxymethyl)phenyl]-;Val-Ala-PAB-OH;(S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide;Val Ala PAB,ValAlaPAB;H-Val-Ala-PAB | | CAS: | 1343476-44-7 | | MF: | C15H23N3O3 | | MW: | 293.36 | | EINECS: | | | Product Categories: | Linker | | Mol File: | 1343476-44-7.mol |  |
| | Val-Ala-PAB Chemical Properties |
| Melting point | 65-68°C | | Boiling point | 584.9±50.0 °C(Predicted) | | density | 1.191±0.06 g/cm3(Predicted) | | storage temp. | -20°C, Inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 13.51±0.70(Predicted) | | form | Solid | | color | White to Off-White |
| | Val-Ala-PAB Usage And Synthesis |
| Description | Val-Ala-PAB-OH is a cleavable ADC linker with a terminal hydroxyl group. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | | Uses | Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing peptide linkers useful for treating proliferative including cancer. |
| | Val-Ala-PAB Preparation Products And Raw materials |
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