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| | WEHI-539 HCl Basic information |
| Product Name: | WEHI-539 HCl | | Synonyms: | WEHI-539 HCl;5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5~{H}-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid;WEHI539 HYDROCHLORIDE ;WEHI 539 HYDROCHLORIDE | | CAS: | 2070018-33-4 | | MF: | C31H30ClN5O3S2 | | MW: | 620.18 | | EINECS: | | | Product Categories: | | | Mol File: | 2070018-33-4.mol |  |
| | WEHI-539 HCl Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≥28.55 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH | | form | solid |
| | WEHI-539 HCl Usage And Synthesis |
| Biological Activity | wehi-539 hydrochloride is a small-molecule inhibitor of bcl xl with ic50 value of 1.1 nm [1].wehi-539 was designed as a bcl-xl inhibitor with high affinity. it interacted with the binding groove of bcl-xl with kd value of 0.6 nm. in mef cells lacking mcl-1, wehi-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome c and caspase-3 processing. in bcl-xl overexpressed mef cells, wehi-539 showed ec50 value of 0.48 μm. wehi-539 also significantly induced apoptosis of the platelets purified from mice. besides that, wehi-539 cannot kill mef cells lacking bak because the cell death mediator bak is regulated by bcl-xl and mcl-1. [1]. | | references | [1]. lessene g, czabotar pe, sleebs be, et al. structure-guided design of a selective bcl-xl inhibitor. nature chemical biology, 2013, 9(6): 390-397. |
| | WEHI-539 HCl Preparation Products And Raw materials |
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