Company Name: |
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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Tel: |
17702719238 17702719238 |
Email: |
sales@sun-shinechem.com |
Products Intro: |
Product Name:ML380 CAS:1627138-52-6 Purity:98% HPLC Package:50.0mg;100.0mg; 200.0mg;500mg;1g;5g; 10g
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Company Name: |
Shanghai Chaolan Chemical Technology Center
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Tel: |
QQ:65489617 15618227136 |
Email: |
info@SuperLan-chem.com |
Products Intro: |
Product Name:ML380 CAS:1627138-52-6 Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Basic information |
Product Name: | N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide | Synonyms: | N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide;ML380;positive,ML380,Muscarinic acetylcholine receptor,allosteric,inhibit,ACh,modulator,Inhibitor,mAChR,PAM;4-Piperidinecarboxamide, N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]- | CAS: | 1627138-52-6 | MF: | C23H25F3N4O3S | MW: | 494.53 | EINECS: | | Product Categories: | | Mol File: | 1627138-52-6.mol | ![N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Structure](CAS/20180528/GIF/1627138-52-6.gif) |
| N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Chemical Properties |
Boiling point | 661.2±65.0 °C(Predicted) | density | 1.388±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO: 100 mg/mL (202.21 mM) | form | Solid | pka | 12.84±0.40(Predicted) | color | White to off-white |
| N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Usage And Synthesis |
Biological Activity | ML380 is a potent, isotype-selective and blood-brain barrier-permeable positive allosteric modulator (PAM) of M5 mAChR with EC50 values of 190 and 610 nM for human and rat M5, respectively. | in vivo | ML380 (1 mg/kg; iv) displays high clearance (66 mL/min/kg), a moderate volume of distribution (1.6 L/kg), and a short half-life (t 1/2 , 22 min) in rats. | target | IC50: 190 nM (hM5), 610 nM (rM5) |
| N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Preparation Products And Raw materials |
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