| Company Name: |
GRK RESEARCH LABORATORIES PVT LTD
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| Tel: |
+91-8249607014 +91-9849401944 |
| Email: |
balaram@grklabs.com |
| Products Intro: |
Product Name:(E)-Ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate
CAS:1215849-96-9
Purity:99% Package:1gm, 5gm, 10gm, 25gm,100gm,1kg or above 1kg needs enquiry
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| Company Name: |
Suzhou yacoo science co.,Ltd
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| Tel: |
0512-87182056 18013166090 |
| Email: |
lingling.qi@yacoo.com.cn |
| Products Intro: |
Product Name:(E)-ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate
CAS:1215849-96-9
Purity:95% by HPLC Package:10g;50g;1kg;5Kg;25kg;
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| Company Name: |
Focus Biomolecules
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| Tel: |
855-362-8721 |
| Email: |
sales@focusbiomolecules.com |
| Products Intro: |
Product Name:FSC-231
Purity:98% by TLCNMR (Conforms) Package:$60.00/5mg;$240.00/25mg;
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| | ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate Basic information |
| | ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate Chemical Properties |
| Melting point | 175-178 °C(Solv: toluene (108-88-3)) | | density | 1.404±0.06 g/cm3(Predicted) | | storage temp. | RT | | solubility | Soluble in DMSO (up to 35 mg/ml with warming) or in Ethanol (up to 18 mg/ml with warming) | | form | solid | | pka | 7.83±0.46(Predicted) | | color | Yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| | ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate Usage And Synthesis |
| Description | FSC-231 (1215849-96-9) is the first small-molecule inhibitor of the PDZ domain in protein interacting with C kinase 1 (PICK1). Binds to PICK1 PDZ domain with affinity similar to that of the endogenous peptide ligands (Ki~10.1 μM). Does not bind to PDZ domains of postsynaptic density protein 95 (PSD-95) nor glutamate receptor interacting protein 1 (GRIP1).? Pretreatment of cultured hippocampal neurons inhibits coimmunoprecipitation of the AMPA receptor GluR2 subunit with PICK1. FSC231 accelerated recycling of fluorophore-tagged GluR2 in hippocampal neurons after internalization in response to NMDA receptor activation. Blocks the expression of both long-term depression and long-term potentiation.1,2 Attenuates cocaine seeking in a rodent model.3 Blocks PICK1-induced anti-inflammatory effect in acute liver injury.4 | | References | 1) Thorsen et al. (2010), Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD; Proc. Natl. Acad. Sci. USA, 107 413
2) Tang et al. (2013), Willed-movement training reduces motor deficits and induces a PICK1-dependent LTD in rats subjected to focal cerebral ischemia; Behav. Brain Res., 256 481
3) Schmidt et al. (2013), Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma; J. Neuroscience, 33 14160
4) Xie et al. (2016), PICK1 confers anti-inflammatory effects in acute liver injury via suppressing M1 macrophage polarization; Biochemie, 127 121 |
| | ethyl 2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate Preparation Products And Raw materials |
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