| Company Name: |
Suzhou Unite pharmTech Co., Ltd ,
|
| Tel: |
792-3901125 13222993784 |
| Email: |
sales@unite-pharm.com |
| Products Intro: |
Product Name:7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol
CAS:352693-80-2
Purity:95% HPLC Package:5g,25g,100g
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| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:MMRi62
CAS:352693-80-2
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
Shanghai Chaolan Chemical Technology Center
|
| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:MMRi62
CAS:352693-80-2
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| | 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol Basic information |
| | 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol Chemical Properties |
| storage temp. | 4°C, protect from light | | solubility | DMSO : 62.5 mg/mL (157.72 mM; ultrasonic and warming and heat to 60°C) | | form | Solid | | color | White to off-white |
| | 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol Usage And Synthesis |
| Description | MMRi62 is an MDM4-degrader and apoptosis inducer in leukemia cells. MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status. MMRi62 effectively induced apoptosis in p53 mutant, multidrug-resistant leukemia cells and patient samples in addition to p53 wild-type cells. In contrast, MMRi67 as a RING heterodimer disruptor and an enzymatic inhibitor of the MDM2-MDM4 E3 complex lacked MDM4-degrader activity and failed to induce apoptosis in these cells. |
| | 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol Preparation Products And Raw materials |
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