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Product Name:Syk Inhibitor CAS:622387-85-3 Purity:>=97%
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| 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Basic information |
Product Name: | 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE | Synonyms: | Syk Inhibitor;3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE;OXSI 2;2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE;1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-;Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation | CAS: | 622387-85-3 | MF: | C18H15N3O3S | MW: | 353.39 | EINECS: | | Product Categories: | pharmacetical;Spleen Tyrosine Kinase Inhibitor | Mol File: | 622387-85-3.mol | |
| 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Chemical Properties |
storage temp. | Store at -20°C | solubility | Soluble in DMSO | form | Orange powder solid. | color | Light yellow to brown | Sensitive | Light Sensitive |
| 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Usage And Synthesis |
Description | Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 14 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change. | Uses | OXSI 2 is a Syk selective inhibitor. |
| 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Preparation Products And Raw materials |
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