861139-16-4
| 中文名称 | 861139-16-4 |
|---|---|
| 中文同义词 | 化合物RSV-IN-1 |
| 英文名称 | N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzenesulfonamide |
| 英文同义词 | Benzenesulfonamide, N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl-1,2,4-triazolo[3,4-a]phthalazin-3-yl)-;RSV-IN-1;N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzenesulfonamide;inhibit,RSV IN 1,Inhibitor,Respiratory syncytial virus,RSV,RSVIN1 |
| CAS号 | 861139-16-4 |
| 分子式 | C20H21N5O4S |
| 分子量 | 427.48 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 861139-16-4.mol |
| 结构式 |  |
861139-16-4 性质
| 密度 | 1.43±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：125 mg/mL (292.41 mM)；水：< 0.1 mg/mL（不溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.21±0.10(Predicted) |
RSV-IN-1 是人呼吸道合胞病毒 (hRSV) 的抑制剂，其 IC50 值为 0.11 μM。
IC50: 0.11μM (hRSV).
The concentration of P13 that reduces the number of RSV plaques in HEp-2 cells by 50% (IC 50 ) is 0.11 μM. The concentration of P13 that reduces the viability of HEp-2 by 50% (CC 50 ) is 310 μM. Note that some cytotoxicity of P13 observed at 500 μM might be due to DMSO solvent. Hence, the selective index (CC 50 /IC 50 ) values is 2818 for P13. Note that even at the relatively high concentrations P13 does not completely block the development of RSV plaques. These escape plaques are of smaller size and of non-syncytial phenotype as compared to plaques formed in the absence of inhibitor.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-112673 | RSV-IN-1 | 1 mg | 1028元 | |
| 2024/08/19 | HY-112673 | 861139-16-4 RSV-IN-1 | 861139-16-4 | 5mg | 2996元 |