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N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide

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N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Suppliers list
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:WAY-323091
CAS:684234-55-7
Purity:98% Package:$296.9/5mg;$474.9/10mg;$939.9/25mg;$1692.9/50mg;$3045.9/100mg;Bulk package Remarks:98%
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ:65489617 15618227136
Email: info@SuperLan-chem.com
Products Intro: Product Name:N-(3-chlorophenyl)-2-(4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl)acetamide
CAS:684234-55-7
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
Company Name: Jingmo (Xiamen) Biotechnology Co., Ltd  
Tel: 13621943973
Email: sales@jamxmpharmatech.com
Products Intro: Product Name:N-(3-chlorophenyl)-2-(4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl)acetamide
CAS:684234-55-7
Purity:98% Package:1g;5g;10g
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
Tel: 15865264761
Email: 486064515@qq.com
Products Intro: Product Name:PARP-1-IN-2
CAS:684234-55-7
Purity:98% Package:500mg；1g；5g
Company Name: Zhengzhou convergence chemical co., LTD  
Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Products Intro: Product Name:N-(3-Chlorophenyl)-2-(4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl)acetamide , PARP-1-IN-2
CAS:684234-55-7
Purity:98% Package:100mg 250mg 500mg 1g 2g 5g 10g 25g 50g 100g 250g 500g 1kg
N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Basic information
Product Name:N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide
Synonyms:N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide;2(1H)-Phthalazineacetamide, N-(3-chlorophenyl)-4-(4-chlorophenyl)-1-oxo-;PARP-1-IN-2;WAY-323091;N-(3-Chlorophenyl)-2-(4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl)acetamide , PARP-1-IN-2
CAS:684234-55-7
MF:C22H15Cl2N3O2
MW:424.28
EINECS:
Product Categories:
Mol File:684234-55-7.mol
N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Structure
N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Chemical Properties
storage temp. 4°C, protect from light
solubility DMSO : 83.33 mg/mL (196.40 mM; Need ultrasonic)
form Solid
color White to off-white
Safety Information
MSDS Information
N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Usage And Synthesis
Biological ActivityPARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis[1]. PARP-1-IN-2 (compound 11g) (0-10 μM, 24-48 h) shows significantly potent anti-proliferative activity against A549 cells[1].PARP-1-IN-2 (0-10 μM, 24 h) decreases the expression of pro-caspase-3 and phosphorylated AKT, increases the expression of caspase-3, caspase-9 protein and the cleaved PARP-1[1].
References[1]. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.
N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Preparation Products And Raw materials
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