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| | ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-3 (FGFR-3), CYTOPLASMIC Basic information |
| Product Name: | ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-3 (FGFR-3), CYTOPLASMIC | | Synonyms: | ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-3 (FGFR-3), CYTOPLASMIC;Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit;Anti-FGFR-3;Anti-Fibroblast Growth Factor Receptor-3, Cytoplasmic antibody produced in rabbit | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-3 (FGFR-3), CYTOPLASMIC Structure]() |
| | ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-3 (FGFR-3), CYTOPLASMIC Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-3 (FGFR-3), CYTOPLASMIC Usage And Synthesis |
| Uses | Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit has been used in:
- immunoblotting
- immunohistochemistry
- immunoprecipitation
| | General Description | FGFR3 (fibroblast growth factor receptor 3) is widely expressed in many fetal and adult human and animal tissues. It belongs to the fibroblast growth factor receptor (Fgfr) family of proteins. It has 19 exons, an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. It is located on human chromosome 4p16.3. | | Biochem/physiol Actions | Fibroblast growth factors (FGFs) are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, and in hematopoiesis as well as in tissue remodeling and maintenance. They have also been implicated in pathological conditions such as tumorigenesis and metastasis. Deletions of chromosome 4p encompassing the FGFR3 (fibroblast growth factor receptor 3) gene cause the Wolf-Hirschhorn syndrome (growth failure, mental retardation, cardiac and bone malformations). Achondroplasia is an inherited disorder in which growth abnormality of bone or cartilage lead to skeletal maldevelopment and dwarfism. It is associated with recurrent mutations of a single amino acid in the transmembrane domain of the FGFR-3 protein. |
| | ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-3 (FGFR-3), CYTOPLASMIC Preparation Products And Raw materials |
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