Compound 48/80 (hydrochloride)
| 中文名称 | Compound 48/80 (hydrochloride) |
|---|---|
| 中文同义词 | 化合物 T13623;复合物48/80三氯化氢 |
| 英文名称 | Compound 48/80 (hydrochloride) |
| 英文同义词 | Compound 48/80 (hydrochloride);C48/80 trihydrochloride;Compound 48/80 trihydrochlorid |
| CAS号 | 848035-21-2 |
| 分子式 | C32H48Cl3N3O3 |
| 分子量 | 629.10082 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 848035-21-2.mol |
| 结构式 |  |
Compound 48/80 (hydrochloride) 性质
| 储存条件 | Store at -20°C, sealed storage, away from moisture ,protect from light |
|---|---|
| 溶解度 | 水：100mM |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride 也是一种组胺 (histamine) 释放剂和肥大细胞 (mast cell) 脱颗粒剂。Compound 48/80 trihydrochloride 抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80.
Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter.
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation.
| Animal Model: | 7-week-old Wistar male rats (fasted for 24 hours) |
| Dosage: | 0.75 mg/kg |
| Administration: | Intraperitoneal injection; Killed after 0.5, 3 or 6 h |
| Result: | Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter. |