Company Name: |
BOC Sciences
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16314854226 |
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info@bocsci.com |
Products Intro: |
Product Name:GM 1489 CAS:171347-75-4 Purity:98% Package:1G;10G;100G Remarks:GM 1489 is a potent broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively.
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Company Name: |
TargetMol Chemicals Inc.
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4008200310 |
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marketing@tsbiochem.com |
Products Intro: |
Product Name:GM 1489 CAS:171347-75-4 Purity:98% Package:1mg/RMB 1270;5mg/RMB 5960
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Company Name: |
Nanjing Tengyi Biotechnology Co., Ltd
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025-58851786 17714337195 |
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sales@tybiochem.com |
Products Intro: |
Product Name:(3R)-3-[[[(1S)-1-(1H-indol-3-ylmethyl)-2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]amino]carbonyl]-5-methyl-hexanoicacid CAS:171347-75-4 Purity:95+% Package:1g;5g
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| GM 1489 Basic information |
Product Name: | GM 1489 | Synonyms: | Hexanoic acid, 3-[[[(1S)-1-(1H-indol-3-ylmethyl)-2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]amino]carbonyl]-5-methyl-, (3R)-;(3R)-3-[[[(1S)-1-(1H-indol-3-ylmethyl)-2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]amino]carbonyl]-5-methyl-hexanoicacid | CAS: | 171347-75-4 | MF: | C27H33N3O4 | MW: | 463.57 | EINECS: | | Product Categories: | | Mol File: | 171347-75-4.mol | |
| GM 1489 Chemical Properties |
Boiling point | 795.4±60.0 °C(Predicted) | density | 1.203±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.2 mg/ml | form | A crystalline solid | pka | 4.71±0.10(Predicted) |
| GM 1489 Usage And Synthesis |
Description | GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2''-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phorbol 12-myristate 13-acetate (TPA; ) and phorbol dibutyrate (PdiBu) in mice. |
| GM 1489 Preparation Products And Raw materials |
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