| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:UCM53
CAS:1449468-52-3
Purity:98% Package:1G;10G;100G Remarks:UCM53 is an inhibitor of bacterial cell division that binds to the GTP site of the cell division protein FtsZ. It inhibits the growth of clinical isolates of antibiotic-resistant Staphylococcus aureus
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:UCM53
CAS:1449468-52-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Product Name: | UCM53 | | Synonyms: | UCM53;Benzoic acid, 3-chloro-4-hydroxy-, 3-[(3,4-dihydroxybenzoyl)oxy]-1-naphthalenyl ester;3-chloro-4-hydroxy-benzoicacid-3-[(3,4-dihydroxybenzoyl)oxy]-1-naphthalenylester | | CAS: | 1449468-52-3 | | MF: | C24H15ClO7 | | MW: | 450.82 | | EINECS: | | | Product Categories: | | | Mol File: | 1449468-52-3.mol |  |
| | UCM53 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | UCM53 Usage And Synthesis |
| Description | UCM53 is an inhibitor of bacterial cell division. It binds to the GTP site of the cell division protein FtsZ from B. subtilis in a fluorescent anisotropy assay. In B. subtilis, UCM53 (3 μM) reduces the number of FtsZ rings and increases the number of foci, as well as induces filamentation when used at a concentration of 12 μM. It is active against laboratory strains and clinical isolates of the Gram-positive bacteria B. subtilis, S. aureus, E. faecium, and E. faecalis (MICs = 2-8 mg/L) but is less effective against S. pneumoniae and the Gram-negative bacteria P. aeruginosa, E. coli, and K. pneumoniae (MICs = 32-128 mg/L). UCM53 inhibits cell growth in a panel of cancerous (IC50s = 16.9-76.5 mg/L) and non-cancerous mammalian cell lines (IC50s = 23.5-93.9 mg/L). |
| | UCM53 Preparation Products And Raw materials |
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