| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:XL413 hydrochloride
CAS:2062200-97-7
Purity:98% Package:1G;10G;100G Remarks:XL413 is a potent and selective inhibitor of Cdc7 with IC50 value of 3.4 nM. It exhibits >60, >10, and >300-fold selectivity for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectiv
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| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
|
| Tel: |
010-60605840 18892239720 |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:XL413 hydrochloride
CAS:2062200-97-7
Purity:98% Package:5mg;10mg;50mg
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| | XL413 (hydrochloride) Basic information |
| | XL413 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO:0.2(Max Conc. mg/mL);0.613(Max Conc. mM)
PBS (pH:7.2):10.0(Max Conc. mg/mL);30.66(Max Conc. mM) | | form | A crystalline solid | | color | White to off-white |
| | XL413 (hydrochloride) Usage And Synthesis |
| Description | XL413 is a potent inhibitor of Cdc7 (IC50 = 3.4 nM). It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of mini-chromosome maintenance protein (MCM2) and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells that overexpress Cdc7. In vivo, XL413 inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model when administered orally at doses of 10, 30, and 100 mg/kg. |
| | XL413 (hydrochloride) Preparation Products And Raw materials |
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