| Company Name: |
Focus Biomolecules
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| Tel: |
855-362-8721 |
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sales@focusbiomolecules.com |
| Products Intro: |
Product Name:PBMC
CAS:1352138-54-5
Purity:98% by TLCNMR (Conforms) Package:$70.00/5mg;$280.00/25mg;
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| | (S)-PBMC
(PBMC) Basic information |
| Product Name: | (S)-PBMC
(PBMC) | | Synonyms: | (S)-PBMC
(PBMC);Carbamic acid, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, (1S)-1-phenylethyl ester | | CAS: | 1352138-54-5 | | MF: | C26H30N2O4 | | MW: | 434.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1352138-54-5.mol |  |
| | (S)-PBMC
(PBMC) Chemical Properties |
| Boiling point | 584.6±50.0 °C(Predicted) | | density | 1.165±0.06 g/cm3(Predicted) | | storage temp. | -20°C (des.) | | solubility | Soluble in DMSO (up to 30 mg/ml). | | pka | 9.17±0.10(Predicted) | | form | oil | | color | Light brown | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| | (S)-PBMC
(PBMC) Usage And Synthesis |
| Description | PBMC (1352138-54-5) is a potent and selective blocker of TRPM8 channels. PBMC blocks both chemical and thermal activation of TRPM8.1?Reverses the menthol and cold-induced facilitation of the micturition reflex.2?PBMC represents a new lead for analgesic drugs based on blocking TRPM8.3 | | References | 1) Knowlton et al. (2011), Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice; PLoS One, 6(9) e25894
2) Gardiner et al. (2014), The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist; Eur. J. Pharmacol., 740 398
3) Salat et al. (2013), Transient receptor potential channels – emerging novel drug targets for the treatment of pain; Curr. Med. Chem., 20 1409 |
| | (S)-PBMC
(PBMC) Preparation Products And Raw materials |
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