| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-Activin A
Purity:affinity isolated antibody, lyophilized powder Package:0.1mg Remarks:A1594
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:affinity isolated antibody, lyophilized powder
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | ANTI-ACTIVIN A Basic information |
| Product Name: | ANTI-ACTIVIN A | | Synonyms: | ANTI-ACTIVIN A;Anti-Activin A antibody produced in goat | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-ACTIVIN A Structure]() |
| | ANTI-ACTIVIN A Chemical Properties |
| storage temp. | -20°C | | form | lyophilized powder |
| | ANTI-ACTIVIN A Usage And Synthesis |
| Uses | Anti-Activin A antibody can be used for immunohistochemistry (5-15 μg/mL), western blot (0.1 μg/mL) and neutralization assays. | | General Description | Activin A protein belongs to the transforming growth factor-β (TGF-β) superfamily. This protein is a homodimer of two βA subunits. The INHBA gene is located on the human chromosome at 7p14.1. | | Biochem/physiol Actions | Activin A protein is involved in regulating developmental genes such as cell cycle regulators like p21, p15, paired box protein (Pax-6) and hormones like follicle-stimulating hormone (FSH). This protein also regulates its antagonist like follistatin and mothers against decapentaplegic homolog 7 (SMAD7). Activin A protein binds to the type 1 receptor activin receptor type 1B (ActR1B) and type 2 receptor activin receptor 2A and 2B (ActRIIA and ActRIIB). Activin A gene is highly expressed in esophageal carcinoma, lung adenocarcinoma, and malignant pleural mesothelioma (MPM). This gene expression is decreased during breast cancer, neuroblastoma, and hepatocellular carcinoma (HCC). Activins bind to the type II Activin receptor triggering phosphorylation of type I Activin receptor (ALK4) and activation of downstream pathways such as proliferation and apoptosis. Activin acts as a tumor suppressor by reducing cell proliferation in cancer cells. |
| | ANTI-ACTIVIN A Preparation Products And Raw materials |
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