8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
中文名称 | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride |
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中文同义词 | 氯氮平N-氧化盐酸;氯氮平N-氧化物二盐酸盐 |
英文名称 | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride |
英文同义词 | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride;Clozapine N-oxide dihydrochloride;Clozapine N-oxide dihydrochloride salt;Clozapine N-oxide diHCl |
CAS号 | 2250025-93-3 |
分子式 | C18H21Cl3N4O- |
分子量 | 415.74454 |
EINECS号 | |
相关类别 | |
Mol文件 | 2250025-93-3.mol |
结构式 | ![]() |
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride 性质
储存条件 | Store at 4°C,stored under nitrogen |
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溶解度 | 溶于二甲基亚砜 |
形态 | 结晶固体 |
颜色 | 橙色 |
水溶解性 | Soluble in water (100 mM). Always store solutions at -20°C. |
Human muscarinic designer receptors (DREADDs)
Clozapine N-oxide (CNO) can bind to non-DREADD receptors at concentrations required for DREADD activation, and undergoes reverse-metabolism to its parent compound clozapine, an atypical antipsychotic that acts at a variety of pharmacological targets and produces numerous physiological and behavioral effects.
After a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Despite the short plasma half-life of CNO in mice, the biological effects that have been described after acute treatment of DREADD-expressing experimental animals are usually much longer (6-10 h).
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-17366A | Clozapine N-oxide dihydrochloride | 1 mg | 340元 | |
2024/04/30 | HY-17366A | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride Clozapine N-oxide dihydrochloride | 2250025-93-3 | 5mg | 750元 |