NSC 663284
| 中文名称 | NSC 663284 |
|---|---|
| 中文同义词 | 化合物 T16357;NSC 663284(DA3003-1),CDC25抑制剂;化合物 DA-3003-1 |
| 英文名称 | NSC 663284 |
| 英文同义词 | CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem;5,8-Quinolinedione, 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]-;CDC25 Phosphatase Inhibitor II, NSC 663284;NSC 663284 (DA3003-1) |
| CAS号 | 383907-43-5 |
| 分子式 | C15H16ClN3O3 |
| 分子量 | 321.76 |
| EINECS号 | |
| 相关类别 | Protein Phosphatase |
| Mol文件 | 383907-43-5.mol |
| 结构式 |  |
NSC 663284 性质
| 沸点 | 478.8±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.41±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：16 毫克/毫升 |
| 形态 | 固体 |
| 酸度系数(pKa) | 6.79±0.10(Predicted) |
| 颜色 | 红色 |
| 敏感性 | Light Sensitive |
| 稳定性 | 可在-20°下的DMSO或乙醇溶液保存长达1个月。 |
IC50: 0.21 μM (Cdc25B2)
NSC 663284 (3-100μM; 48 hours) has a mean IC 50 value in the NCI 60 Cell human tumor panel of 1.5 ± 0.6 μM, has IC 50 values of 0.2 μM in human breast cancer MDA-MB-435 and MDA-N cells, has an IC 50 value of 1.7 μM in human breast MCF-7 cells in culture. NSC 663284 has relative IC 50 values for Cdc25B2 (IC 50 =0.21 μM) are 20- and 450-fold lower than for VHR (IC 50 =4.0 μM) or PTP1B (IC 50 >4.0 μM), respectively.
NSC 663284 (intravenous injection; 2, 3, and 5mg/kg) inhibits the growth of subcutaneous human colon HT29 xenografts in SCID mice. After a single dose of 5 mg/kg, NSC 663284 is not detectable in plasma or tissues beyond 5 min. Following NSC 663284 treatment of tumor-bearing SCID mice, reduces glutathione concentrations in HT29 tumor are decreased to a greater extent and remained decreased for longer than the reduced glutathione concentrations in liver and kidneys.