| Company Name: |
Changzhou Chenhong Biotechnology Co., Ltd.
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| Tel: |
0519-85788828 13775037613 |
| Email: |
sales@chemrenpharm.com |
| Products Intro: |
Product Name:GLP26
CAS:2133017-36-2
Purity:99% Package:50mg;100mg;250mg;500mg;1g;5g
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| Product Name: | GLP-26 | | Synonyms: | GLP-26;GLP-26;GLP 26;GLP26;inhibit,GLP26,GLP 26,Inhibitor,GLP-26,Hepatitis B virus,HBV;1H-Pyrrole-3-acetamide, 5-[[(3,4-difluorophenyl)amino]carbonyl]-1,2,4-trimethyl-α-oxo-N-2-propyn-1-yl-;N-(3,4-difluorophenyl)-1,3,5-trimethyl-4-(2-oxo-2-(prop-2-yn-1-ylamino)acetyl)-1H-pyrrole-2-carboxamide | | CAS: | 2133017-36-2 | | MF: | C19H17F2N3O3 | | MW: | 373.36 | | EINECS: | | | Product Categories: | | | Mol File: | 2133017-36-2.mol |  |
| | GLP-26 Chemical Properties |
| density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 125 mg/mL (334.81 mM) | | form | Solid | | pka | 10.99±0.46(Predicted) | | color | Light yellow to brown |
| | GLP-26 Usage And Synthesis |
| Description | GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM.GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools[1]. GLP-26 (0.7-1.7 μM; 3 days) reduces secreted HBeAg in HepNTCP-DL cells transfected with HBVwild type, with EC50 values of 0.7 μM[2]. Cell Viability Assay[2] Cell Line: HepNTCP-DL cells | | References | [1]. Nijampatnam B, et al. Recent advances in the development of HBV capsid assembly modulators. Curr Opin Chem Biol. 2019 Jun;50:73-79. |
| | GLP-26 Preparation Products And Raw materials |
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