| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:RA-9
CAS:919091-63-7
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
|
|
| Product Name: | RA-9 | | Synonyms: | 4-Piperidinone, 3,5-bis[(4-nitrophenyl)methylene]-, (3E,5E)-;RA-9 UPS inhibitor;Unfolded,RA-9,cancer,RA 9,DUBs,Inhibitor,Apoptosis,Response,Deubiquitinase,cells,inhibit,Protein,ovarian,RA9,survival | | CAS: | 919091-63-7 | | MF: | C19H15N3O5 | | MW: | 365.34 | | EINECS: | | | Product Categories: | | | Mol File: | 919091-63-7.mol |  |
| Melting point | 230-233 °C(Solv: ethyl ether (60-29-7); acetonitrile (75-05-8)) | | Boiling point | 588.5±50.0 °C(Predicted) | | density | 1.414±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 4.17 mg/mL (11.41 mM; ultrasonic and warming and heat to 80°C) | | pka | 5.13±0.20(Predicted) | | form | Solid | | color | Light yellow to yellow |
| Biological Activity | RA-9 is a potent and selective inhibitor of cell-permeable proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity and anticancer activity. It selectively induces apoptosis in ovarian cancer cell lines. | | in vivo | RA-9 (5 mg/kg; ip; one-day on, two-days off) inhibits human ovarian cancer cell growth in vivo and prolongs survival in a mouse model for ovarian cancer. < td class="col1 fwb"> Animal Model: | Six-week-old female immunodeficient (NCr nu/nu) mice | | Dosage: | 5 mg/kg | | Administration: | Ip; one-day on, two-days off | | Result: | Significant reduction in tumor burden at day 12. | | | target |
| | RA-9 Preparation Products And Raw materials |
|
|
Tag:RA-9(919091-63-7)
Related Product Information
|
|
|
According to the laws, regulations and policies related to "patent products", the sale of this product is prohibited!
ChemicalBook prompt
The patent owner or licensee of the product has not released any relevant information for the time being.
|