| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:15-LOX-1 inhibitor 1
CAS:2349374-37-2
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:9c(i472)
CAS:2349374-37-2
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| | 9c(i472) Basic information |
| Product Name: | 9c(i472) | | Synonyms: | 9c(i472);15-LOX-1 inhibitor 1;1H-Indole-2-carboxylic acid, 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-, ethyl ester;6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-1H-indole-2-carboxylic acid, ethyl ester | | CAS: | 2349374-37-2 | | MF: | C22H21ClN2O4 | | MW: | 412.87 | | EINECS: | | | Product Categories: | | | Mol File: | 2349374-37-2.mol |  |
| | 9c(i472) Chemical Properties |
| Boiling point | 683.5±55.0 °C(Predicted) | | density | 1.305±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble; Methanol: slightly soluble | | form | A crystalline solid | | pka | 13.41±0.30(Predicted) | | color | Off-white to light yellow |
| | 9c(i472) Usage And Synthesis |
| Description | 9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF-?B activity in RAW-Blue? cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM. | | References | 1. Guo, H., Verhoek, I.C., Prins, G.G.H., et al. Novel 15-lipoxygenase-1 inhibitor protects macrophages from lipopolysaccharide-induced cytotoxicity J. Med. Chem. 62(9),4624-4637(2019). |
| | 9c(i472) Preparation Products And Raw materials |
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