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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
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Product Name:IM-93 CAS:1173657-73-2 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Company Name: |
TargetMol Chemicals Inc.
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4008200310 |
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marketing@tsbiochem.com |
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Product Name:IM-93 CAS:1173657-73-2 Purity:98% Package:100 mg;5 mg;50 mg
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Company Name: |
Nanjing Tengyi Biotechnology Co., Ltd
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025-58851786 17714337195 |
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sales@tybiochem.com |
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Product Name:3-[[3-(dimethylamino)propyl]amino]-1-(1-methylethyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione CAS:1173657-73-2 Purity:95+% Package:1g;5g
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Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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Tel: |
021-65675885 18964387627 |
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customer_service@efebio.com |
Products Intro: |
Product Name:IM-93 CAS:1173657-73-2 Purity:98% Package:1mg;5mg;10mg
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Product Name: | IM-93 | Synonyms: | IM-93;1H-Pyrrole-2,5-dione, 3-[[3-(dimethylamino)propyl]amino]-1-(1-methylethyl)-4-(1-methyl-1H-indol-3-yl)-;3-[[3-(dimethylamino)propyl]amino]-1-(1-methylethyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | CAS: | 1173657-73-2 | MF: | C21H28N4O2 | MW: | 368.47 | EINECS: | | Product Categories: | | Mol File: | 1173657-73-2.mol | ![IM-93 Structure](CAS/20210111/GIF/1173657-73-2.gif) |
| IM-93 Chemical Properties |
Boiling point | 540.2±50.0 °C(Predicted) | density | 1.17±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMF: 20mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL; Ethanol: 1mg/mL | form | A crystalline solid | pka | 9.48±0.28(Predicted) |
| IM-93 Usage And Synthesis |
Description | IM-93 is a dual inhibitor of ferroptosis and NETosis.1 It inhibits tert-butyl hydroperoxide- and erastin-induced ferroptosis in NIH3T3 cells (IC50s =1.8 and 1.9 nM, respectively), as well as decreases NETosis and lipid peroxidation induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human peripheral blood neutrophils when used at concentrations ranging from 1.6 to 25 μM. IM-93 also inhibits hydrogen peroxide-induced necrosis in HL-60 cells (IC50 = 0.45 μM), but has no effect on necroptosis induced by Fas ligand in combination with Z-VAD-FMK and cycloheximide in Jurkat cells or pyroptosis induced by S. aureus and P. aeruginosa in THP-1 cells when used at a concentration of 25 μM. | References | 1. Dodo, K., Kuboki, E., Shimizu, T., et al. Development of a water-soluble indolylmaleimide derivative IM-93 showing dual inhibition of ferroptosis and NETosis ACS Med. Chem. Lett. 10(9),1272-1278(2019). |
| IM-93 Preparation Products And Raw materials |
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