| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:PYD-106
CAS:1560894-05-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
|
| | PYD-106 Basic information |
| Product Name: | PYD-106 | | Synonyms: | PYD-106;PYD106,PYD 106;4-[3-acetyl-2,5-dihydro-4-hydroxy-1-[2-(2-methyl-1H-indol-3-yl)ethyl]-5-oxo-1H-pyrrol-2-yl]-benzoic acid, methyl ester | | CAS: | 1560894-05-4 | | MF: | C25H24N2O5 | | MW: | 432.47 | | EINECS: | | | Product Categories: | | | Mol File: | 1560894-05-4.mol |  |
| | PYD-106 Chemical Properties |
| Boiling point | 723.0±60.0 °C(Predicted) | | density | 1.339±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A solid | | pka | 4.50±1.00(Predicted) |
| | PYD-106 Usage And Synthesis |
| Biological Activity | PYD-106 is a positive allosteric modulator of NR2C subunit-containing NMDA receptors (NMDARs).1 It enhances glutamate-induced maximal current responses in HEK293 cells expressing NR1/NR2C NMDA receptors (EC50 = 13 μM). PYD-106 is selective for NR2C subunit-containing NMDA receptors over NRA-, NR2B-, and NR2D-subunit containing NMDA receptors in Xenopus oocytes expressing NR1/NR2 heteromeric NMDA receptors at 30 μM. | | References | 1.Khatri, A., Burger, P.B., Swanger, S.A., et al.Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulatorMol. Pharmacol.86(5)548-560(2014) |
| | PYD-106 Preparation Products And Raw materials |
|