| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-Breast Cancer Resistance Protein
Purity:affinity isolated antibody, buffered aqueous solution Package:200μL Remarks:B7185
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| | ANTI-BCRP Basic information |
| Product Name: | ANTI-BCRP | | Synonyms: | MONOCLONAL ANTI-BREAST CANCER RESISTANCE PROTEIN;MONOCLONAL ANTIBODY TO BREAST CANCER RESISTANCE PROTEIN (BCRP, MXR) (HUMAN) (BXP-21);MONOCLONAL ANTIBODY TO BREAST CANCER RESISTANCE PROTEIN (BCRP, MXR) (HUMAN) (BXP-34);ANTI-ABCG2;ANTI-ABCG2 (HUMAN);ANTI-BCRP;ANTI-BCRP (HUMAN);ANTI-BREAST CANCER RESISTANCE PROTEIN | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-BCRP Structure]() |
| | ANTI-BCRP Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-BCRP Usage And Synthesis |
| Uses | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper) | | General Description | Anti-Breast Cancer Resistance Protein is developed in rabbit using as immunogen a synthetic peptide of human breast cancer resistance protein (BCRP). BCRP, also designated ABCG2, ABCP, placenta specific ATP-binding transporter and mitoxantrone-resistance protein (MXR), is a member of the ABCG subfamily of the large ATP binding cassette (ABC) transporter family of transmembrane proteins. BCRP is a half-transporter, with a single ATP binding cassette and transmembrane region. BCRP is normally expressed in human placental syncytiotrophoblasts, mammary ducts and lobules, endothelial cells and stem cells of different tissues. | | Biochem/physiol Actions | Up regulation of breast cancer resistance protein (BCRP) expression may be found in vivo and in vitro in both drugs treated and untreated tumors of different types. Breast cancer resistance protein transports various xenobiotics to the extracellular space through a process energized by ATP hydrolysis. In addition, to its role in protecting cells and tissues against xenobiotics especially in the intestine, liver, placenta and the blood-brain barrier, BCRP appears to be involved in hypoxic defense mechanisms and the protection and regulation of stem cells. |
| | ANTI-BCRP Preparation Products And Raw materials |
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