| Company Name: |
Nanjing Chemlin Chemical Co., Ltd
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| Tel: |
025-83697070 13913916777 |
| Email: |
info@chemlin.com.cn |
| Products Intro: |
Product Name:2-Chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]acetamide
CAS:568544-03-6
Purity:98% Package:5KG;1KG
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| | 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE Basic information |
| Product Name: | 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE | | Synonyms: | 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE;GSTO1 inhibitor 1;Acetamide, 2-chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]-;2-Chloro-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)acetamide;GSTO1-IN-1;2-Chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]acetamide;GSTs,GSTO1IN1,Glutathione transferases,inhibit,Inhibitor,Gutathione S-transferase,GSTO1 IN 1,GSTO-1-IN-1 | | CAS: | 568544-03-6 | | MF: | C10H12Cl2N2O3S | | MW: | 311.18 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | Solid | | color | Light yellow to yellow |
| | 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE Usage And Synthesis |
| Biological Activity | GSTO1-IN-1 is a potent glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 31 nM. | | in vitro | GSTO1-IN-1 (C1-27) potently inhibits GSTO1 enzyme activity with an IC 50 value of 31 nM. GSTO1-IN-1 also potently competes with 5-chloromethylfluorescein diacetate (CMFDA) for binding to recombinant protein, as well as endogenous GSTO1 in the milieu of a soluble proteome. HCT116 cells treated with GSTO1-IN-1 also show a decrease in cell viability in a dose-dependent manner. GSTO1-IN-1 inhibits the clonogenic survival of HCT116 cells at sub-micromolar concentrations. | | target | |
| | 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE Preparation Products And Raw materials |
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