| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 15221909166 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:Methyl 2-amino-5-heptylthiophene-3-carboxylate
CAS:1522415-97-9
Purity:98% Package:10mg;25mg;50mg;100mg Remarks:BD01353994
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| Product Name: | TJ191 | | Synonyms: | TJ191;cancer,TJ 191,Apoptosis,PMBC,MOLT-3,CEM,inhibit,C8166,Inhibitor,MOLT-4,MT-2,TJ191,HSB-2,TJ-191,SUP-T1,JURKAT;3-Thiophenecarboxylic acid, 2-amino-5-heptyl-, methyl ester;Methyl 2-amino-5-heptylthiophene-3-carboxylate | | CAS: | 1522415-97-9 | | MF: | C13H21NO2S | | MW: | 255.38 | | EINECS: | | | Product Categories: | | | Mol File: | 1522415-97-9.mol |  |
| | TJ191 Chemical Properties |
| Boiling point | 370.3±42.0 °C(Predicted) | | density | 1.089±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 100 mg/mL (391.57 mM; Need ultrasonic) | | pka | 0.40±0.10(Predicted) | | form | Solid | | color | Light yellow to khaki |
| | TJ191 Usage And Synthesis |
| Biological Activity | TJ191 is a potent and specific anti-cancer agent that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. TJ191 has no affects on the proliferation of other cancer cells or normal fibroblasts or immune cells. TJ191 can be used for cancer research[1].
TJ191(0-100 μM; 24 hours) exhibits pronounced anti-proliferative activity in malignant cell lines, the IC50 values are 0.13 μM, 0.13±0.08 μM, 0.26±0.19 μM, 0.22±0.11 μM, 1.5±0.02 μM, 0.32±0.086 μM, 3.1±0.5 μM, 0.26±0.16 μM in CEM, JURKAT, MOLT-3, MOLT-4, SUP-T1, MT-2, C8166 and HSB-2 cells, respectively. But has no effects in HUT-78 (IC50=17±10 μM) and MT-4 (IC50=47 ± 5 μM) cells[1].TJ191 (0.1-3 μM; 8 or 24 hours) induces CEM cell apoptosis in a concentration- and time-dependent manner. Even at 0.3 μM, TJ191 induces the maximum apoptotic rate of 80% after 24 h[1]. | | References | [1]. Ahmed El-Gazzar, et al. 2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. Oncotarget. 2017 Dec 15;9(5):6259-6269. |
| | TJ191 Preparation Products And Raw materials |
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