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Benzeneacetic acid, 4-[[[[[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]-

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Benzeneacetic acid, 4-[[[[[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]- Suppliers list
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:RORγt inverse agonist 13
CAS:2170477-75-3
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shanghai Chaolan Chemical Technology Center  
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Email: info@SuperLan-chem.com
Products Intro: Product Name:RORγt inverse agonist 13
CAS:2170477-75-3
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
Company Name: Shanghai Dongyang Biotechnology Co., Ltd.  
Tel: 0512-0512-13601744364 13601744364
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Products Intro: Product Name:RORγt inverse agonist 13
CAS:2170477-75-3
Purity:98% Package:1g 5g 10g 25g 50g 100g
Company Name: Shanghai Zhongzechuan Pharmaceutical Technology Co., LTD  
Tel: 15021253307
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Products Intro: Product Name:RORγt inverse agonist 13
CAS:2170477-75-3
Purity:95% Package:1g;5g; 10g
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Email: marketing@tsbiochem.com
Products Intro: Product Name:RORγt inverse agonist 13
CAS:2170477-75-3
Purity:99% Package:1mg/RMB 495;5mg/RMB 1180;10mg/RMB 1950
Benzeneacetic acid, 4-[[[[[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]- Basic information
Product Name:Benzeneacetic acid, 4-[[[[[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]-
Synonyms:Benzeneacetic acid, 4-[[[[[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]-;RORγt inverse agonist 13;RORγt inverse agonist 13,ROR,RORγt inverse agonist-13,RAR-related orphan receptor,inhibit,RORγt inverse agonist13,Inhibitor;Benzeneacetic acid, 4-[[[[[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]-
CAS:2170477-75-3
MF:C23H17Cl2F3N2O4
MW:513.29
EINECS:
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Mol File:2170477-75-3.mol
Benzeneacetic acid, 4-[[[[[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]- Structure
Benzeneacetic acid, 4-[[[[[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]- Chemical Properties
Boiling point 552.9±50.0 °C(Predicted)
density 1.470±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (194.82 mM; Need ultrasonic)
pka4.30±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Benzeneacetic acid, 4-[[[[[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]- Usage And Synthesis
Biological ActivityRORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM[1]. RORγt inverse agonist 13 (Compound 3i) exhibits activity with an inhibition of 76% at 0.3 μM in Th17 cell differentiation assay[1]. RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, Orally, twice daily) demonstrats excellent in vivo PK profile in mice and good in vivo efficacy in an IMQ-induced psoriasis mice model[1].
References[1]. Nannan Sun, et al. Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists. Eur J Med Chem. 2020 Jul 5;202:112536.
Benzeneacetic acid, 4-[[[[[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]- Preparation Products And Raw materials
Tag:Benzeneacetic acid, 4-[[[[[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]amino]carbonyl]amino]methyl]-(2170477-75-3) Related Product Information