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Methanone, [3-fluoro-2-(2-pyrimidinyl)phenyl][(1S,2R,4R)-2-[[5-(trifluoromethyl)-2-pyrazinyl]amino]-7-azabicyclo[2.2.1]hept-7-yl]-

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Methanone, [3-fluoro-2-(2-pyrimidinyl)phenyl][(1S,2R,4R)-2-[[5-(trifluoromethyl)-2-pyrazinyl]amino]-7-azabicyclo[2.2.1]hept-7-yl]- Suppliers list
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Products Intro: Product Name:JNJ-54717793
CAS:1628843-99-1
Purity:98 Package:500mg；1g；5g；10g；25g Remarks:Provide customized services
Company Name: Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd  
Tel: 15317229551
Email: 15151849396@163.com
Products Intro: Product Name:JNJ-54717793
CAS:1628843-99-1
Purity:98% HPLC Package:1g
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Email: marketing@tsbiochem.com
Products Intro: Product Name:JNJ-54717793
CAS:1628843-99-1
Purity:98% Package:10 mg；25 mg
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd  
Tel: 024-024-88590548 18341751992
Email: 757984502@qq.com
Products Intro: Product Name:JNJ-54717793
CAS:1628843-99-1
Purity:98% HPLC Package:1g;5g
Methanone, [3-fluoro-2-(2-pyrimidinyl)phenyl][(1S,2R,4R)-2-[[5-(trifluoromethyl)-2-pyrazinyl]amino]-7-azabicyclo[2.2.1]hept-7-yl]- Basic information
Product Name:Methanone, [3-fluoro-2-(2-pyrimidinyl)phenyl][(1S,2R,4R)-2-[[5-(trifluoromethyl)-2-pyrazinyl]amino]-7-azabicyclo[2.2.1]hept-7-yl]-
Synonyms:Methanone, [3-fluoro-2-(2-pyrimidinyl)phenyl][(1S,2R,4R)-2-[[5-(trifluoromethyl)-2-pyrazinyl]amino]-7-azabicyclo[2.2.1]hept-7-yl]-;JNJ-54717793
CAS:1628843-99-1
MF:C22H18F4N6O
MW:458.41
EINECS:
Product Categories:
Mol File:1628843-99-1.mol
Methanone, [3-fluoro-2-(2-pyrimidinyl)phenyl][(1S,2R,4R)-2-[[5-(trifluoromethyl)-2-pyrazinyl]amino]-7-azabicyclo[2.2.1]hept-7-yl]- Structure
Methanone, [3-fluoro-2-(2-pyrimidinyl)phenyl][(1S,2R,4R)-2-[[5-(trifluoromethyl)-2-pyrazinyl]amino]-7-azabicyclo[2.2.1]hept-7-yl]- Chemical Properties
Boiling point 558.6±50.0 °C(Predicted)
density 1.459±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 240 mg/mL (523.55 mM; Need ultrasonic)
pka1.35±0.10(Predicted)
form Solid
color Off-white to pink
Safety Information
MSDS Information
Methanone, [3-fluoro-2-(2-pyrimidinyl)phenyl][(1S,2R,4R)-2-[[5-(trifluoromethyl)-2-pyrazinyl]amino]-7-azabicyclo[2.2.1]hept-7-yl]- Usage And Synthesis
Biological ActivityJNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC50=85 ng/mL). The Ki values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders[1][2]. JNJ-5471779 (30 mg/kg; p.o.; 6 hours) significantly reduces the latency for rapid eye movement (REM) sleep and prolongs the time spent in REM sleep[2].JNJ-5471779 (3~30 mg/kg; p.o.) attenuates bradycardia responses[2].JNJ-5471779 (5mg/kg; p.o.) shows low clearance[1].
References[1]. Préville C, et al. Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793. ACS Med Chem Lett. 2020;11(10):2002-2009. Published 2020 Apr 27. [2]. Bonaventure P, et al. Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation. Front Pharmacol. 2017;8:357. Published 2017 Jun 9.
Methanone, [3-fluoro-2-(2-pyrimidinyl)phenyl][(1S,2R,4R)-2-[[5-(trifluoromethyl)-2-pyrazinyl]amino]-7-azabicyclo[2.2.1]hept-7-yl]- Preparation Products And Raw materials
Tag:Methanone, [3-fluoro-2-(2-pyrimidinyl)phenyl][(1S,2R,4R)-2-[[5-(trifluoromethyl)-2-pyrazinyl]amino]-7-azabicyclo[2.2.1]hept-7-yl]-(1628843-99-1) Related Product Information