| Company Name: |
Levena (Suzhou) Biopharma Co., Ltd. Gold
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| Tel: |
0512-81877925 051281877925 |
| Email: |
info@levena.cn |
| Products Intro: |
Product Name:DUO-5
CAS:2124210-34-8
Purity:99% Package:1g/RMB 13000;10g100g
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| Company Name: |
Zhejiang Huida Biotech Co., LTD
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| Tel: |
0571-89903882 15990081639 |
| Email: |
sunshixuan@huidabiotech.com |
| Products Intro: |
Product Name:DUO-5
CAS:2124210-34-8
Purity:98% Package:1g;10g;100g
|
| Company Name: |
QUALITY CONTROL SOLUTIONS LTD.
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| Tel: |
0755-66853366; 13670046396 |
| Email: |
ORDERS@QCSRM.COM |
| Products Intro: |
Product Name:Unii-CE421mmy47
CAS:2124210-34-8
Purity:95% HPLC Package:10MG;25MG;50MG;100MG
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| | (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((S)-1-(4-aminophenyl)-3-azidopropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamide Basic information |
| | (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((S)-1-(4-aminophenyl)-3-azidopropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamide Chemical Properties |
| form | Solid | | color | White to off-white |
| | (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((S)-1-(4-aminophenyl)-3-azidopropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamide Usage And Synthesis |
| Uses | Duostatin 5 is a cytotoxin designed based on dolastatin, can meet the requirement of serving as an effective cytotoxin in ADC, but has the advantages of fewer synthesis steps, easy operation, less difficulty in quality control and more stable chemical synthesis process[1]. Duostatin 5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | References | [1] Toxin for antibody drug conjugate and preparation method thereof. CN107857798B. |
| | (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((S)-1-(4-aminophenyl)-3-azidopropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamide Preparation Products And Raw materials |
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