| Company Name: |
Suzhou Zhixin Biotechnology Co., Ltd.
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| Tel: |
0512-65118909 15162312715 |
| Email: |
sales@szzxbio.com |
| Products Intro: |
Product Name:NVS-PI3-4
CAS:941580-60-5
Purity:98%+ Package:1g;10g;100g
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Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- manufacturers
- NVS-PI3-4
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- $1590.00 / 100mg
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2024-10-28
- CAS:941580-60-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- Basic information |
| | Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- Chemical Properties |
| density | 1.211±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 250 mg/mL (621.10 mM; Need ultrasonic) | | form | Solid | | pka | 6.48±0.70(Predicted) | | color | Off-white to yellow |
| | Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- Usage And Synthesis |
| Biological Activity | NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases[1][2].
NVS-PI3-4 shows an exquisite cellular selectivity for PI3Kγ. NVS-PI3-4 reduces IgE/antigen-mediated phosphorylation of PKB/Akt in p110δDA. NVS-PI3-4 (5 μM; 30 minutes; BMMCs) is not accumulate in specifically in mast cells[2]. | | References | [1]. Bruce I, et al. Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorg Med Chem Lett. 2012;22(17):5445-5450. [2]. Collmann E, et al. Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells’ route to allergy. J Allergy Clin Immunol. 2013;132(4):959-968. |
| | Propanamide, 3-[[[[5-(4-acetylphenyl)-4-methyl-2-thiazolyl]amino]carbonyl]amino]-N-(1,1-dimethylethyl)- Preparation Products And Raw materials |
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