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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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| Products Intro: |
Product Name:OxafluMazine Succinate
CAS:7450-97-7
Package:100Mg,10Mg
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Energy Chemical
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021-58432009 400-005-6266 |
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| Products Intro: |
Product Name:Oxaflumazine Succinate
CAS:7450-97-7
Purity:NULL Package:100mg;10mg Remarks:NULL
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| Company Name: |
CLEARSYNTH LABS LTD.
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sales@clearsynth.com |
| Products Intro: |
Product Name:Oxaflumazine disuccinate D8
CAS:7450-97-7
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| | succinic acid, compound with 10-[3-[4-[2-(1,3-dioxan-2-yl)ethyl]piperazin-1-yl]propyl]-2-(trifluoromethyl)-10H-phenothiazine (2:1) Basic information |
| | succinic acid, compound with 10-[3-[4-[2-(1,3-dioxan-2-yl)ethyl]piperazin-1-yl]propyl]-2-(trifluoromethyl)-10H-phenothiazine (2:1) Chemical Properties |
| Melting point | 136-138° | | color | Crystals from acetonitrile |
| Toxicity | LD50 in mice (mg/kg): 94 i.v.; 175 i.p.; 919 orally (Boissier, Dumont) |
| | succinic acid, compound with 10-[3-[4-[2-(1,3-dioxan-2-yl)ethyl]piperazin-1-yl]propyl]-2-(trifluoromethyl)-10H-phenothiazine (2:1) Usage And Synthesis |
| Originator | Oxaflumine, Diamant ,France,1970 | | Uses | Oxaflumazine Succinate, is a novel anti-inflammatory drug-like compound. It is also an Antipsychotic. | | Manufacturing Process | Preparation of N-(3-chloropropyl)-N'-[2-(1,3-dioxanyl)-ethyl]-piperazine: A solution of 30 g (0.15 mol) of N-[2-(1,3-dioxanyl)-ethyl]-piperazine and 11.8 g (0.075 mol) of 1-bromo-3-chloropropane in 150 ml of dry benzene was refluxed with stirring for 5 hours. After cooling, the N-[2-(1,3-dioxanyl)ethyl]-piperazinium bromide which had precipitated was filtered off, the filtrate was concentrated in vacuo and the residual oil was distilled. 14.1 g (68%yield) of N-(3-chloropropyl)-N'-[2-1,3-dioxanyl)-ethyl]-piperazine which occurred as a light yellow oil were obtained. Boiling point: 152°C to 155°C under 0.07 mm Hg (nD23 = 1.4940). The disuccinate prepared in acetone and recrystallized from acetone melts at 104°C to 105°C on a hot stage microscope.
The sodium derivative of the 2-trifluoromethylphenothiazine was prepared from 26.7 g (0.1 mol) of 2-trifluoromethylphenothiazine and 2.3 g (0.1 g atom) of sodium in 500 ml of liquid ammonia. After the reaction was completed, the ammonia was driven off and 500 ml of dry toluene were added. A solution of 25 g (0.09 mol) of N-(3-chloropropyl)-N'-[2-(1,3dioxanyl)-ethyl]-piperazine in 200 ml of toluene was added drop by drop to this solution which was then refluxed with stirring for 18 hours. After cooling, the precipitate which had formed was filtered and the filtrate was washed with water, dried and concentrated in vacuo. 33 g of brown oil, the N-3-(2trifluoromethyl-10-phenothiazinyl)-propyl-N'-2-[2-(1,3-dioxanyl)]-ethylpiperazine, were obtained.
A warm solution of 4.4 g of the base obtained in 100 ml of acetonitrile was added to a warm solution of succinic acid in 200 ml of acetonitrile. After standing for 15 hours at 0°C. the crystalline product was obtained, melting point 138°C. | | Therapeutic Function | Neuroleptic, Antihistaminic, Spasmolytic | | Safety Profile | Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of Fí, NOx, and SOx. |
| | succinic acid, compound with 10-[3-[4-[2-(1,3-dioxan-2-yl)ethyl]piperazin-1-yl]propyl]-2-(trifluoromethyl)-10H-phenothiazine (2:1) Preparation Products And Raw materials |
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