Company Name: |
TargetMol Chemicals Inc.
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Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:JNJ-42253432 CAS:1428327-35-8 Purity:99.08% Package:1mg/RMB 1180;5mg/RMB 2930;10mg/RMB 4180
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Company Name: |
Suzhou Zhixin Biotechnology Co., Ltd.
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Tel: |
0512-65118909 15162312715 |
Email: |
sales@szzxbio.com |
Products Intro: |
Product Name:JNJ-42253432 CAS:1428327-35-8 Purity:98%+ Package:1g;10g;100g
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| JNJ-42253432 Basic information |
Product Name: | JNJ-42253432 | Synonyms: | JNJ-42253432;JNJ42253432,JNJ 42253432;5-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-2-methyl-N-[[1-(4-phenyl-1-piperazinyl)cyclohexyl]methyl]- | CAS: | 1428327-35-8 | MF: | C28H38N4O | MW: | 446.63 | EINECS: | | Product Categories: | | Mol File: | 1428327-35-8.mol | |
| JNJ-42253432 Chemical Properties |
Boiling point | 592.8±50.0 °C(Predicted) | density | 1.130±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | pka | 16.14±0.20(Predicted) | form | Solid | color | White to off-white |
| JNJ-42253432 Usage And Synthesis |
Biological Activity | JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively[1].
When dosed in rats, JNJ-42253432 occupied the brain P2X7 channel with an ED50 of 0.3 mg/kg, corresponding to a mean plasma concentration of 42 ng/ml. JNJ-42253432 also increased serotonin levels in the rat brain, which is due to antagonism of the serotonin transporter (SERT) resulting in an ED50 of 10 mg/kg for SERT occupancy[1]. | References | [1]. Brian Lord, et al. Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432. J Pharmacol Exp Ther. 2014 Dec;351(3):628-41. |
| JNJ-42253432 Preparation Products And Raw materials |
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