| Company Name: |
Merck KGaA
|
| Tel: |
(+86) 21 2033 8288 |
| Email: |
sigmaname@qq.com |
| Products Intro: |
Product Name:PF-06807656
CAS:2213468-04-1
|
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Email: |
info@biorbyt.com |
| Products Intro: |
Product Name:PF-06807656
|
|
| | PF-06807656 Basic information |
| Product Name: | PF-06807656 | | Synonyms: | PF-06807656;Benzamide, 3-[[(4-chlorophenyl)amino]sulfonyl]-4-methoxy-N-[1-(2-methyl-2H-1,2,3-triazol-4-yl)ethyl]- | | CAS: | 2213468-04-1 | | MF: | C19H20ClN5O4S | | MW: | 449.91 | | EINECS: | | | Product Categories: | | | Mol File: | 2213468-04-1.mol |  |
| | PF-06807656 Chemical Properties |
| density | 1.43±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | pka | 7.35±0.10(Predicted) | | form | powder | | color | white to beige |
| | PF-06807656 Usage And Synthesis |
| Biological Activity | PF-06807656 is a 3-sulfamoylbenzamide-based renal outer medullary potassium channel (ROMK, CCNJ1, Kir1.1) inhibitor (IC50 = 61 nM by whole cell patch clamp) th at is insensitive to K80M or N171D pore mutation and exhibits high selectivity for human over r at species (IC50 against thallium sulfate/TlSO4-stimulated influx = 391 nM vs. >30 μM using human or r at ROMK1-expressing HEK293 cells; 82% vs. 0% inhibition by patch clamp using human or r at ROMK2-expressing HEK293 cells). |
| | PF-06807656 Preparation Products And Raw materials |
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