P-MPPI MONOHYDROCHLORIDE
| 中文名称 | P-MPPI MONOHYDROCHLORIDE |
|---|---|
| 中文同义词 | 化合物P-MPPI HYDROCHLORIDE;4-碘-N-(2-(4-(2-甲氧基苯基)哌嗪-1-基)乙基)-N-(吡啶-2-基)苯甲酰胺盐酸盐;P-MPPI MONOHYDROCHLORIDE盐酸盐 |
| 英文名称 | P-MPPI MONOHYDROCHLORIDE |
| 英文同义词 | P-MPPI MONOHYDROCHLORIDE;4-iodo-n-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl)benzamide monohydrochloride;Benzamide,4-iodo-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-,monohydrochloride;4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide:hydrochloride;4-iodo-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)benzamide hydrochloride (1:1);p MPPI hydrochloride,inhibit,affinity,sleep,5-hydroxytryptamine Receptor,5-HT Receptor,selective,Serotonin Receptor,pMPPI hydrochloride,antidepressant-like,anxiety,p-MPPI,Inhibitor,ligand,disorders;p-MPPIHCl |
| CAS号 | 220643-77-6 |
| 分子式 | C25H27IN4O2HCl |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 220643-77-6.mol |
| 结构式 |  |
P-MPPI MONOHYDROCHLORIDE 性质
| 储存条件 | Inert atmosphere,Room Temperature |
|---|---|
| 溶解度 | 二甲基亚砜：17.86 mg/mL（30.85 mM） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
p-MPPI hydrochloride 是一种选择性的，具有高亲和力的 5-HT1A 受体拮抗剂。p-MPPI hydrochloride 能穿过血脑屏障，具有明显的抗抑郁和抗焦虑作用。
|
5-HT 1A Receptor
|
p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity.
p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze.
| Animal Model: | Adult male Swiss Webster mice (aged 8-9 weeks) |
| Dosage: | 0.5, 1.5, 4.5 mg/kg |
| Administration: | i.p. |
| Result: | Produced a significant and dose-related anxiolytic profile on both conventional (open arm avoidance) and ethological (risk assessment) measures. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2023/01/06 | S0880 | P-MPPI MONOHYDROCHLORIDE p-MPPI hydrochloride | 220643-77-6 | 5mg | 2841.93元 |
| 2023/01/06 | S0880 | P-MPPI MONOHYDROCHLORIDE p-MPPI hydrochloride | 220643-77-6 | 25mg | 8591.31元 |