| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:SRI-41315
CAS:1613509-49-1
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
Aikon International Limited
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| Tel: |
025-66113011 18112977050 |
| Email: |
cb6@aikonchem.com |
| Products Intro: |
CAS:1613509-49-1
Purity:95% Package:1g;5g;10g
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:2-Cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione
CAS:1613509-49-1
Purity:98% Package:5mg;10mg;25mg;50mg;100mg; Remarks:BD01474741
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:SRI-41315
CAS:1613509-49-1
Purity:98% Package:100 mg；5 mg；50 mg
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| Company Name: |
Dongyang Qiusuo Medical Technology Co., LTD
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| Tel: |
17502510579 |
| Email: |
2785299132@qq.com |
| Products Intro: |
Product Name:Pyrimido[4,5- b]quinoline-4,5(3H ,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-
CAS:1613509-49-1
Package:100mg,1g，100g
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| | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Basic information |
| Product Name: | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- | | Synonyms: | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-;SRI-41315;2-Cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione | | CAS: | 1613509-49-1 | | MF: | C22H19N3O2 | | MW: | 357.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1613509-49-1.mol | ![Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Structure](CAS/20210305/GIF/1613509-49-1.gif) |
| | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Chemical Properties |
| Boiling point | 495.3±55.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | pka | 2.41±0.20(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Usage And Synthesis |
| Description | SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. SRI-41315 induce a prolonged pause at stop codons and suppress PTCs associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity. |
| | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Preparation Products And Raw materials |
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