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1H-Pyrido[3,4-b]indole, 1-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-2,3,4,9-tetrahydro-3-methyl-2-(methylsulfonyl)-, (1R,3R)-

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1H-Pyrido[3,4-b]indole, 1-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-2,3,4,9-tetrahydro-3-methyl-2-(methylsulfonyl)-, (1R,3R)- Suppliers list
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:GNE-502
CAS:1953134-16-1
Purity:99% Package:$250.9/1mg;$750.9/5mg;$1200.9/10mg;Bulk package Remarks:99%
1H-Pyrido[3,4-b]indole, 1-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-2,3,4,9-tetrahydro-3-methyl-2-(methylsulfonyl)-, (1R,3R)- Basic information
Product Name:1H-Pyrido[3,4-b]indole, 1-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-2,3,4,9-tetrahydro-3-methyl-2-(methylsulfonyl)-, (1R,3R)-
Synonyms:1H-Pyrido[3,4-b]indole, 1-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-2,3,4,9-tetrahydro-3-methyl-2-(methylsulfonyl)-, (1R,3R)-;GNE-502
CAS:1953134-16-1
MF:C25H30FN3O3S
MW:471.59
EINECS:
Product Categories:
Mol File:1953134-16-1.mol
1H-Pyrido[3,4-b]indole, 1-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-2,3,4,9-tetrahydro-3-methyl-2-(methylsulfonyl)-, (1R,3R)- Structure
1H-Pyrido[3,4-b]indole, 1-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-2,3,4,9-tetrahydro-3-methyl-2-(methylsulfonyl)-, (1R,3R)- Chemical Properties
Boiling point 658.4±65.0 °C(Predicted)
density 1.35±0.1 g/cm3(Predicted)
solubility DMSO : 100 mg/mL (212.05 mM; Need ultrasonic)
form Solid
pka16.75±0.60(Predicted)
color White to off-white
Safety Information
MSDS Information
1H-Pyrido[3,4-b]indole, 1-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-2,3,4,9-tetrahydro-3-methyl-2-(methylsulfonyl)-, (1R,3R)- Usage And Synthesis
Biological ActivityGNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer[1]. GNE-502 (10 and 100 mg/kg; p.o.) possesses sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model[1].GNE-502 shows dose dependent tumor growth inhibition at 10 mg/kg and 30 mg/kg, with tumor stasis at 100 mg/kg[1].
References[1]. Zbieg JR, et al. Discovery of GNE-502 as an Orally Bioavailable and Potent Degrader for Estrogen Receptor Positive Breast Cancer [published online ahead of print, 2021 Aug 20]. Bioorg Med Chem Lett. 2021;128335.
1H-Pyrido[3,4-b]indole, 1-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-2,3,4,9-tetrahydro-3-methyl-2-(methylsulfonyl)-, (1R,3R)- Preparation Products And Raw materials
Tag:1H-Pyrido[3,4-b]indole, 1-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-2,3,4,9-tetrahydro-3-methyl-2-(methylsulfonyl)-, (1R,3R)-(1953134-16-1) Related Product Information