| Company Name: |
Shaoyuan Technology (Shanghai) Co., Ltd.
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| Tel: |
021-50795510 4000665055 |
| Email: |
sy-c6@accelachem.com |
| Products Intro: |
Product Name:Methyl [4-[(4-Fluorobenzyl)(2-propyn-1-yl)amino]-2,6-dimethylphenyl]carbamate
CAS:1821222-10-9
Purity:>=95% Package:0.1g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:HN37
CAS:1821222-10-9
Package:50mg/RMB 21222;25mg/RMB 16300
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| | Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester Basic information |
| | Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester Chemical Properties |
| Boiling point | 452.2±45.0 °C(Predicted) | | density | 1.210±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 50 mg/mL (146.89 mM; Need ultrasonic) | | pka | 13.39±0.70(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester Usage And Synthesis |
| Biological Activity | HN37 as a potent and chemically stable antiepileptic drug candidate, with an EC50 of 37 nM for KCNQ2[1].
HN37 is a potent neuronal Kv7 activator with a subtype selectivity similar to RTG[1]. | | References | [1]. Yang-Ming Zhang, et al. Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate. J Med Chem. 2021 May 13;64(9):5816-5837. |
| | Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester Preparation Products And Raw materials |
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