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| 1-Piperazinecarboxylic acid, 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-, 1,1-dimethylethyl ester Basic information |
Product Name: | 1-Piperazinecarboxylic acid, 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-, 1,1-dimethylethyl ester | Synonyms: | 1-Piperazinecarboxylic acid, 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-, 1,1-dimethylethyl ester;SGC-SMARCA-BRDVIII;Epigenetic Reader Domain,adipogenesis,SMARCA2/4,inhibit,PB1,SGCSMARCABRDVIII,Inhibitor,SGC SMARCA BRDVIII;tert-butyl 4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazine-1-carboxylate | CAS: | 1997319-84-2 | MF: | C19H25N5O3 | MW: | 371.43 | EINECS: | | Product Categories: | | Mol File: | 1997319-84-2.mol | |
| 1-Piperazinecarboxylic acid, 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-, 1,1-dimethylethyl ester Chemical Properties |
Boiling point | 599.6±50.0 °C(Predicted) | density | 1.270±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : 25 mg/mL (67.31 mM; ultrasonic and warming and heat to 60°C) | pka | 8.82±0.51(Predicted) | form | Solid | color | Off-white to yellow |
| 1-Piperazinecarboxylic acid, 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-, 1,1-dimethylethyl ester Usage And Synthesis |
Biological Activity | SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2].
SGC-SMARCA-BRDVIII (compound 22) (1 μM; 14 days) blocks adipocyte differentiation in 3T3-L1 murine fibroblasts[1]. | storage | Store at -20°C | References | [1]. Wanior M, et, al. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J Med Chem. 2020 Dec 10;63(23):14680-14699. [2]. Mélin L, et, al. Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2. ACS Omega. 2021 Aug 9;6(33):21327-21338. |
| 1-Piperazinecarboxylic acid, 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-, 1,1-dimethylethyl ester Preparation Products And Raw materials |
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