| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:DS45500853
CAS:2735803-28-6
Purity:详情请点击官网 Package:1 mg
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| | Ethanone, 1-[4-[3-(1,1-dimethylethyl)-4-hydroxyphenoxy]phenyl]- Basic information |
| | Ethanone, 1-[4-[3-(1,1-dimethylethyl)-4-hydroxyphenoxy]phenyl]- Chemical Properties |
| Boiling point | 412.8±45.0 °C(Predicted) | | density | 1.107±0.06 g/cm3(Predicted) | | solubility | DMSO : 50 mg/mL (175.84 mM; ultrasonic and warming and heat to 60°C) | | pka | 11.23±0.20(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | Ethanone, 1-[4-[3-(1,1-dimethylethyl)-4-hydroxyphenoxy]phenyl]- Usage And Synthesis |
| Biological Activity | DS45500853 is an estrogen-related receptor α (ERRα) agonist. DS45500853 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an IC50 value of 0.80 μM. DS45500853 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM)[1].
DS45500853 (compound 5c; 0.002, 0.006, 0.017, 0.051, 0.015, 0.046, 1.4, 4.2, 12.5 μg/mL; 18 h) inhibits the transcriptional activity of full-length ERRα in MG63 cells with an EC50 of 5.4 μM[1].DS45500853 binds in the ligand-binding pocket (LBP) of the ERRα LBD as inverse agonist II[1]. | | References | [1]. Shinozuka T, et al. Discovery of a Novel Class of ERRα Agonists. ACS Med Chem Lett. 2021 Apr 21;12(5):817-821. |
| | Ethanone, 1-[4-[3-(1,1-dimethylethyl)-4-hydroxyphenoxy]phenyl]- Preparation Products And Raw materials |
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